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Humanoid character setup. Mecanim has a special workflow for humanoid models, with extended GUI support and retargeting. The setup involves creating and setting up an Avatar and tweaking Muscle definitions.
Generic character setup. This is for anything like creatures, animated props, four-legged animals, etc. Retargeting is not possible here, but you can still take advantage of the rich feature set of Mecanim, including everything described below.