GUITexture.pixelInset
var pixelInset: Rect;
Rect pixelInset;
pixelInset as Rect
Description

Pixel inset used for pixel adjustments for size and position.

You can set the transform.localScale to Vector3.zero in order to make the GUI texture always the same pixel size.
	transform.position = Vector3.zero;
	transform.localScale = Vector3.zero;
	guiTexture.pixelInset = Rect (50, 50, 100, 100);
using UnityEngine;
using System.Collections;

public class Example : MonoBehaviour {
    void Example() {
        transform.position = Vector3.zero;
        transform.localScale = Vector3.zero;
        guiTexture.pixelInset = new Rect(50, 50, 100, 100);
    }
}
import UnityEngine
import System.Collections

public class Example(MonoBehaviour):

	def Example() as void:
		transform.position = Vector3.zero
		transform.localScale = Vector3.zero
		guiTexture.pixelInset = Rect(50, 50, 100, 100)