renderer.material.mainTexture.filterMode = FilterMode.Point;

using UnityEngine;
using System.Collections;

public class example : MonoBehaviour {
    void Example() {
        renderer.material.mainTexture.filterMode = FilterMode.Point;
    }
}

import UnityEngine
import System.Collections

class example(MonoBehaviour):

    def Example():
        renderer.material.mainTexture.filterMode = FilterMode.Point