It’s possible to use Surface ShadersA program that runs on the GPU. More info
See in Glossary with custom vertex streams, although there are some extra things to be aware of:
appdata_particles.uv. To prevent the automatic handling from causing problems here, be sure to give your UV inputs different names (for example, “texcoord”).Here is the same functionality as the Standard Shader, but in a Surface Shader:
Shader "Particles/Anim Alpha Blend Surface" {
    Properties {
        _Color ("Color", Color) = (1,1,1,1)
        _MainTex ("Albedo (RGB)", 2D) = "white" {}
        _Glossiness ("Smoothness", Range(0,1)) = 0.5
        _Metallic ("Metallic", Range(0,1)) = 0.0
    }
    SubShader {
        Tags {"Queue"="Transparent" "RenderType"="Transparent"}
        Blend SrcAlpha OneMinusSrcAlpha
        ZWrite off
        LOD 200
        
        CGPROGRAM
        // Physically based Standard lighting model, and enable shadows on all light types
        #pragma surface surf Standard alpha vertex:vert
        // Use shader model 3.0 target, to get nicer looking lighting
        #pragma target 3.0
        sampler2D _MainTex;
         struct appdata_particles {
            float4 vertex : POSITION;
            float3 normal : NORMAL;
            float4 color : COLOR;
            float4 texcoords : TEXCOORD0;
            float texcoordBlend : TEXCOORD1;
            };
        struct Input {
            float2 uv_MainTex;
            float2 texcoord1;
            float blend;
            float4 color;
        };
        void vert(inout appdata_particles v, out Input o) {
            UNITY_INITIALIZE_OUTPUT(Input,o);
            o.uv_MainTex = v.texcoords.xy;
            o.texcoord1 = v.texcoords.zw;
            o.blend = v.texcoordBlend;
            o.color = v.color;
          }
        half _Glossiness;
        half _Metallic;
        fixed4 _Color;
        void surf (Input IN, inout SurfaceOutputStandard o) {
            fixed4 colA = tex2D(_MainTex, IN.uv_MainTex);
            fixed4 colB = tex2D(_MainTex, IN.texcoord1);
            fixed4 c = 2.0f * IN.color * lerp(colA, colB, IN.blend) * _Color;
                 
            o.Albedo = c.rgb;
            // Metallic and smoothness come from slider variables
            o.Metallic = _Metallic;
            o.Smoothness = _Glossiness;
            o.Alpha = c.a;
        }
        ENDCG
    }
    FallBack "Diffuse"
}