// build a matrix from a transform.
var matrix = Matrix4x4();

/// Build a matrix from a transform.
function Start () {
    matrix.SetColumn (0, transform.right);
    matrix.SetColumn (1, transform.up);
    matrix.SetColumn (2, transform.forward);
    var p = transform.position;
    matrix.SetColumn (3, Vector4 (p.x, p.y, p.z, 1));
}

using UnityEngine;
using System.Collections;

public class example : MonoBehaviour {
    public Matrix4x4 matrix = new Matrix4x4();
    void Start() {
        matrix.SetColumn(0, transform.right);
        matrix.SetColumn(1, transform.up);
        matrix.SetColumn(2, transform.forward);
        Vector3 p = transform.position;
        matrix.SetColumn(3, new Vector4(p.x, p.y, p.z, 1));
    }
}

import UnityEngine
import System.Collections

class example(MonoBehaviour):

    public matrix as Matrix4x4 = Matrix4x4()

    def Start():
        matrix.SetColumn(0, transform.right)
        matrix.SetColumn(1, transform.up)
        matrix.SetColumn(2, transform.forward)
        p as Vector3 = transform.position
        matrix.SetColumn(3, Vector4(p.x, p.y, p.z, 1))